Paired chemostratigraphic and biostratigraphic data suggest that the Devonian–Carboniferous boundary and the Hangenberg extinction event are recorded in the Coffee Pot Member of the Dyer Formation of the White River uplift region of northwestern Colorado. The Hangenberg isotopic excursion interval occurs in biostratigraphically depauperate shallow platform micritic dolostone and limestone representing the aculeatus–?ultimus–kockeli? Zone. The Hangenberg interval strata have δ13Ccarb values up to 7.69‰, and locally contain ooids, stromatolites, and other microbial structures. In three sections, there is a short-lived > 4‰ “pre-Hangenberg” positive excursion that is associated with the presence of detrital dolomite siltstone. The main Hangenberg isotopic signature exists in overlying strata, and is replicated in four different sections of the Dyer Formation across an area ~300 km2. In each section, the excursion interval is preceded by, and in one location is interrupted by, evidence of meteoric diagenesis and/or emergence characterized by macroscopic dissolution features and pronounced negative δ13Ccarb values (to ca. -6‰). Conodont 87Sr/86Sr ratios through the Dyer Formation dip to nearly 0.708 during the onset of the Hangenberg Event, consistent with the brachiopod based 87Sr/86Sr nadir from the same interval in Missouri, France, and Germany. The least-radiogenic trendline through the Dyer 87Sr/86Sr record matches the global minimum 87Sr/86Sr trendline through the Famennian–Tournaisian transition and infills several gaps in the global record.