The study area is located in middepth to deep waters of the Salina del Istmo Basin where Repsol operates Block 29. The objective of this work is to integrate qualitative and quantitative interpretations of rock and seismic data to predict lithology and fluid of the Early Miocene prospects. The seismic expression of those prospects differs from age-equivalent well-studied analog fields in the U.S. Gulf of Mexico Basin due to the mineralogically complex composition of abundant extrusive volcanic material. Offset well data (i.e., core, logs, and cuttings) were used to discriminate lithology types and to quantify mineralogy. This analysis served as input for developing a new rock-physics framework and performing amplitude variation with offset (AVO) modeling. The results indicate that the combination of intercept and gradient makes it possible to discriminate hydrocarbon-filled (AVO class II and III) versus nonhydrocarbon-filled rocks (AVO class 0 and IV). Different lithologies within hydrocarbon-bearing reservoirs cannot be discriminated as the gradient remains negative for all rock types. However, AVO analysis allows discrimination of three different reservoir rock types in water-bearing cases (AVO class 0, I, and IV). These conclusions were obtained during studies conducted in 2018–2019 and were used in prospect evaluation to select drilling locations leading to two wildcat discoveries, the Polok and Chinwol prospects, drilled in Block 29 in 2020.