The deposition of the presalt section from Santos Basin began when Gondwana started to break up and South America and Africa were separating. Initial synrift carbonate deposits affected by relatively severe tectonic activity evolved to a lacustrine carbonate environment during the later stages of basin formation. Although the reservoirs are composed of carbonate rocks, the occurrence of faults and the intense colocation of igneous rocks served as a source of chemical elements uncommon in typical carbonate environments. Consequently, beyond the presence of different facies with complex textures and pore geometries, the presalt reservoir rocks present marked compositional and microstructural variability. Therefore, rock-physics modeling is used to understand and interpret the extensive laboratory measurements of P-wave velocities, S-wave velocities, and density that we have undertaken on the presalt carbonate cores from Santos Basin. We show that quartz and exotic clay minerals (such as stevensite and other magnesium-rich clay minerals), which have different values of elastic moduli and Poisson's ratio as compared to calcite and dolomite, may introduce noticeable “Poisson's reflectivity anomalies” on prestack seismic data. Moreover, although the authors concentrate their attention on composition, it will become clear that pore-space geometry also may influence seismic rock properties of presalt carbonate reservoirs.