In the process of quantifying resources/reserves, geoscientists attempt to employ all the available pertinent information to produce the most accurate results. The presence of direct hydrocarbon indicators (DHI) on seismic data can have a significant impact on the reserve/resource calculations not only for volumes, but also uncertainty levels. In 2001 a consortium of oil companies was organized in an attempt to understand seismic amplitude anomalies interpreted as DHIs and their impact on prospect risking and resource calculations (Roden et al., 2005; Forrest et al., 2010). The geologic setting, seismic and rock physics data quality, DHI characteristics, and calibration of drilling results are all incorporated into a database in a consistent and systematic process. From this process, the evaluation of 217 prospects and associated well results has enabled an in-depth understanding of the relevant key aspects of seismic amplitude anomalies and how they relate to drilling results.