Following the development of unconventional oil and gas production in the Fort Worth Basin, Texas, a rapid increase in basin‐wide seismicity began in 2008 that grew to include earthquakes affecting a substantial portion of the Dallas–Fort Worth metropolitan area. To assess and mitigate the seismic hazard, which in this region is impacted by the thickness of the sedimentary basin and accompanying soft soil layer, we estimate site effects at 22 seismic stations deployed to record these earthquakes. Site responses are derived using two different datasets and approaches: (1) a modified generalized inversion technique (GIT) based on the S‐wave Fourier amplitude spectra from earthquakes; and (2) application of the quarter‐wavelength approximation (QWA) using estimates of average shear‐wave velocities in the upper 30 m, known as . We find that site amplification estimates based on the two techniques are roughly consistent with one another (median of the amplification ratio = 0.92) over frequencies where a quarter‐wavelength corresponds to ∼30 m depth. The site amplification factors from the two approaches are found on average to be about 3 at the quarter‐wavelength frequency (QWF). These site amplification estimates are not well correlated with geologic characteristics including rock type and geologic age. Finally, QWA values at six sites do not match GIT site amplification at the QWF (outside of ± median absolute deviations boundary), which we attribute to a combination of the underlying assumptions of the QWA, uncertainty in estimates, and unmodeled site response complexity.