Seismic structural health monitoring allows for the continuous evaluation of engineering structures by monitoring changes in the structural response that can potentially localize associated damage that has occurred. For the first time in Colombia, a permanent and continuous monitoring network has been deployed in a 14‐story ecofriendly steel‐frame building combined with a reinforced concrete structure in downtown Bogota. The six three‐component ETNA‐2 accelerometers recorded continuously for 225 days between July 2019 and February 2020. We use deconvolution‐based seismic interferometry to calculate the impulse response function (IRF) using earthquake and ambient‐vibration data and a stretching technique to estimate velocity variations before and after the 6.0 Mesetas earthquake and its aftershock sequence. A consistent and probably permanent velocity variation (2% reduction) is detected for the building using ambient‐vibration data. In contrast, a 10% velocity reduction is observed just after the mainshock using earthquake‐based IRFs showing a quick recovery to about 2%. A combination of both earthquake‐based and ambient‐vibration‐based deconvolution interferometry provides a more complete picture of the state of health of engineering structures.