An historically unprecedented seismic moment was released by crustal events of the 2019–2020 earthquake sequence near southwest Puerto Rico. The sequence involved at least two, and perhaps three interacting fault systems. The largest 6.4 event was likely triggered by left lateral strike‐slip events along the eastern extension of the North Boquerón Bay‐Punta Montalva fault zone. The mainshock occurred in a normal fault zone that extends into a region where previous studies documented extensional deformation, beyond the Ponce fault and the Bajo Tasmanian fault. Coulomb stress changes by the mainshock may have triggered further normal‐faulting aftershocks, left lateral strike‐slip events in the region where these two fault zones interacted, and possibly right lateral strike‐slip aftershocks along a third structure extending southward, the Guayanilla fault zone. Extension directions of the seismic sequence are consistently north‐northwest–south‐southeast‐oriented, in agreement with the Global Navigation Satellite Systems‐inferred motion direction of eastern Hispaniola relative to western Puerto Rico, and with crustal stress estimates for the overriding plate boundary zone.