Causes of intraplate seismicity remain a great unsolved problem, in contrast with plate‐boundary seismicity. Modern seismicity records frequent seismic activity in plate‐boundary seismic zones, but in fault zones where seismic activity is not frequent, plate boundary or intraplate, resolution of prehistoric earthquake activity is critical for estimating earthquake recurrence interval and maximum expected magnitude. Thus, documenting prehistoric earthquakes is crucial for assessing earthquake hazard posed to infrastructure, including nuclear reactors and large dams. The ∼400 km long eastern Tennessee seismic zone (ETSZ), United States, is the third most active seismic zone east of the Rocky Mountains in North America, although the largest recorded ETSZ earthquake is only 4.8. Ironically, it is the least studied major eastern U.S. seismic zone. Recent ETSZ field surveys revealed an 80 km long, 060°‐trending corridor containing northeast‐striking Quaternary thrust, strike slip, and normal faults with displacements ≥1 m. It partially overlaps a parallel trend of seismicity that extends 30 km farther southwest, suggesting this active faulting zone may extend ∼110 km within part of the ETSZ. Near Dandridge, Tennessee, a thrust fault in French Broad River alluvium records two earthquakes in the last 40,000 yr. About 50 km southwest near Alcoa, Tennessee, a thrust fault cuts Little River alluvium and records two earthquakes between 15,000 and 10,000 yr ago. About 30 km farther southwest at Vonore, Tennessee, a thrust fault displaces bedrock ≥2 m over colluvium, and alluvium is normal faulted >2 m. This corridor, just west of the Blue Ridge escarpment, overlies a steep gradient in midcrustal S‐wave velocities, consistent with a basement fault at hypocentral depths. The corridor faults may be connected to a basement fault or localized coseismic faults above a blind basement fault. Our current data suggest at least two surface rupturing events in the last 40,000 yr.