Eight large nuclear explosions in Novaya Zemlya, from October 1969, through November 1974, were used to monitor long-term variations in crustal seismic velocity near the San Andreas fault in central California. Relative P-wave travel-time residuals appear to be accurate to approximately ±0.1 sec. Of the over 100 stations used, none show clearly significant temporal variations in residual greater than this amount, corresponding to about a 4 per cent change in velocity in the upper crust. Average relative residuals at individual stations show a large spatial variation of about 1.5 sec. These variations reflect both a complex crustal geology and changes in crustal thickness and provide a potentially powerful tool for studying crustal structure.