The Automated Event Location Using a Mesh of Arrays (AELUMA) method, originally developed for detection of atmospheric sources using infrasonic data, is modified here to detect and locate seismic events. A key feature of AELUMA is that it does not require a detailed velocity model to locate events. The new method was applied to vertical‐component seismic data recorded by the USArray Transportable Array to (1) test its efficacy when applied to a very large dataset, (2) test its ability to detect and accurately locate distinct event types across a geologically diverse region without analyst oversight, and (3) assess the sensitivity and accuracy of the method. Using data filtered from 1 to 8 Hz, 9996 events were detected in clusters within the central United States—with most events located near areas known for anthropogenic activity. The method was compared with three catalogs in Oklahoma—a region known for small anthropogenic events. In comparison with accurate locations from a template study, AELUMA detected all events from but none below 1.3. The median absolute origin time and location offset were 9.5 s and 6.0 km, respectively. Comparisons of AELUMA’s catalog in Oklahoma with two others (produced by Oklahoma Geological Survey [OGS] and the Array Network Facility) showed that AELUMA found more events than either catalog, including clusters of emergent events that were largely missed by the other methods. However, most of the smaller magnitude events detected by OGS were missed by AELUMA, mainly due to the sparser network used by AELUMA.