Italy has a historical earthquake record that is complete for events with a magnitude above 5.8 since A.D. 1349, making it possible to study Coulomb failure stress changes () over a long period. In this study, we investigated the interactions between moderate‐to‐large earthquakes through over 100 yr in central Italy. This region is characterized by intense seismicity with predominantly extensional components. Hence, earthquake hazard assessment is of great public concern. Besides, earthquake interactions on normal faults are relatively less studied compared to reverse and strike‐slip faults. calculations in this study incorporated both coseismic stress transfer and postseismic viscoelastic relaxation, and found the epicenters of 13 out of 15 events located in positively stressed lobes induced by previous earthquakes, confirming a correlation between the pattern and locations of moderate‐to‐large earthquakes. Next, we estimated the current distribution of on active faults, and after a comprehensive analysis of accumulation, slip rates, historical seismicity, and locations of populated cities, we identified three regions of potential seismic hazards in this region.