A probabilistic seismic hazard analysis has been performed to compute probabilistic seismic hazard maps for the eastern Caribbean region (10° N–19° N, 59° W–64° W), which includes in the north the Leeward Islands (from Anguilla to Dominica) and in the south the Windward Islands (from Martinique to Grenada), Barbados, Trinidad, and Tobago. The analysis has been conducted using a standard logic-tree approach that allowed systematically taking into account the model-based (i.e., epistemic) uncertainty and its influence on the computed ground motion parameters. Hazard computations have been performed using a grid of sites with a space resolution of 0.025 degrees covering the territory of the considered islands. Two different computation methodologies have been adopted: the standard Cornell–McGuire approach (Cornell, 1968; McGuire, 1976) based on the definition of appropriate seismogenic zones (SZ), and the zone-free approach developed by Woo (1996), which overcomes the ambiguities related with the definition of seismic sources. The interplay and complexities between shallow crustal, intraplate, and interface subduction seismicity of the Caribbean region have been thoroughly investigated. By merging all available databases, a comprehensive and updated earthquake catalog for the region has been compiled. Also, a thorough investigation has been undertaken to identify the most suitable ground motion prediction equations to be used in the analyses. Uniform hazard spectra have been calculated for the horizontal component of ground motion (rock and level site conditions), 4 return periods (RP) (95-, 475-, 975-, and 2475-yr), and 22 spectral accelerations (SA) with structural periods ranging from 0 to 3 s. SAs at 0.2 and 1.0 s for 2475-yr RP have been calculated to allow the definition of seismic hazard in the region of study according to the International Building Code (IBC, International Code Council [ICC], 2009).