U-Pb zircon and Rb-Sr geochronological, and Sm-Nd isotopic studies have been carried out on the so-called leptyno-amphibolitic complex of the central part of the Maures Massif. The emplacement of the protolith of the felsic end-member (« leptynites ») has been dated at 548 Ma, an age much older than those (lower Ordovician) previously obtained on other leptyno-amphibolitic complexes. Rb-Sr data obtained on whole rocks and on mineral separates give an age of 348 Ma for the amphibolite-facies metamorphism. Nd isotopes indicate that the amphibolites display clear-cut mantle-derived signatures, whereas a significant crustal contribution is recorded in the three analyzed felsic facies. One of these acidic terms can be interpreted in terms of a simple mixing between two components, respectively similar to the amphibolites and to the two other felsic samples. These latter involve another mantle source, distinct from that of the amphibolites, and comparable to that of continental alkali basalts. These data indicate that the central part of the Maures Massif and the southern Massif Central were possibly part of the same pre-Variscan structural unit. The lack of evidence for a clear genetic relationship between the respective protoliths of the two end-members of the leptyno-amphibolitic complex raises once again the problem of the geodynamic significance of these formations.