The high resolution stratigraphy and fossil assemblage analyses of a carbonate system in the eastern United-Arab-Emirates and Oman suggest the existence of a causal link between palaeodepth, stratigraphic accommodation, carbonate factory and ecosystem evolution. Geodynamic and sequence stratigraphic analyses reveal changes in relative sea-level, whereas a detailed study of fossil associations allows us to establish their concurrent modifications related to change in accommodation space. This multidisciplinary approach should allow to improve prediction of geometric carbonate reservoir distribution and evaluate the bulk of carbonate factory associated with regressive and transgressive tendencies. The Simsima Formation, Maastrichtian (late Cretaceous) in age, has recorded a wide variety of carbonate depositional systems that evolve from coastal plain to outer shelf deposits. This stratigraphic unit includes buildups composed of red algae, rudists and corals, sensitive to relative sea-level fluctuations, and bioaccummulations characterized by isolated corals and benthic foraminifera. The palaeogeographic reconstruction across the Cretaceous-Tertiary transition suggests that seafloor was differentiated into topographic highs and lows that influenced the syndepositional processes recorded in the Simsima Formation.