This study focuses on a regional comparison of interpretations from selected 2D seismic transects between large salt and salt-free basins offshore southern Brazil (Espirito Santo basin, Campos basin, Santos basin, and Pelotas basin) and southwest Africa (Kwanza basin, Benguela basin, Namibe basin, and Walvis basin). Based on tectonostratigraphic analysis of megasequences and first-pass geometric reconstructions of synrift settings, including sedimentary decompaction and isostatic correction, it provides a comprehensive basin-to-basin documentation of the key geological parameters controlling asymmetries in basin evolution. The diversity in the tectonic and stratigraphic architecture of the conjugate margin basins reflects variations in the interplay of a number of controlling factors, of which the most important are: (A) the structural configuration of each margin segment at the time of break up; (B) the postbreakup subsidence/uplift history of the respective margin segment; (C) variations in the type, quantity, and distribution of margin sediment (including salt); (D) the evolution of the large salt basins during sag to postsag stages; and (E) sea-level changes.