The ancient Moldanubian structure of the Bohemian Massif probably was poor in ore deposits. The upper Proterozoic and Paleozoic geosynclinal development and regional metamorphism effected a new redistribution and supply of material and are believed to be metallogically of the highest importance. A model of a process that might enrich some zones and areas in ore-forming constituents is given.Units with characteristic structure and development in the Bohemian Massif contain specific types of mineralization. These types of endogenous, mainly hydrothermal mineralization have been defined as isogenous mineral associations. Two main and different groups of Variscan intrusives, each with a different source and each with related isogenous mineral associations, form two principal petrometallogenic groups.The main accumulations of the endogenous mineralization of both petrometallogenic groups are distributed along the weakened zones of the margins of the former geosynclinal basins. The ore manifestations follow the deep-seated faults and are dispersed into the surrounding wall rocks. The relatively stable blocks are mostly barren of ores. The geological development and metallogeny of other Precambrian massifs in central and western Europe might be in many respects similar.