The Imiter Ag-Hg deposit is located in the Precambrian volcano-sedimentary formations of the Saghro inlier (eastern part of the Anti-Atlas Mountains, Morocco). The orebodies consist of northeast-southwest to east-west veins and lenses hosted by Cryogenian black shales and gray-wackes and Neoproterozoic conglomerates, and are controlled by an east-west fault network, the so-called Imiter fault. Mineralogical and paleo-fluid geochemistry investigations (microthermometry, Raman spectroscopy, LA-ICP-MS on individual inclusions, bulk crush-leach analyses, and stable isotope data (O, H)) show that the main Ag ore stage is related to circulation of deep-basinal sedimentary brines (Na-K-(Mg) (salinity = 16.7 to ≥26 wt % NaCl equiv, molar Cl/Br = 330, δ18O = 2.15–2.35‰SMOW, and δD = −53.8 to −65.5‰SMOW), at temperatures of about 180° to 220°C and hydrostatic pressures. The main driving mechanism for silver ore deposition is the dilution of ore-bearing brines by a low-salinity meteoric fluid containing a low-density volatile component (N2 > CH4 > CO2), Th = 180° to 220°C, δ18O = −1.4‰SMOW, and δD of about −28.2‰SMOW. Silver content of the brines ranges from 2 to 30 mmol/kg solution (up to 3,200 ppm Ag, avg Ag concentration about 900 ppm), whereas the maximum Ag content found in dilute waters is about 0.4 mmol/kg solution (40 ppm). The ore-forming model proposed for the Imiter deposit is (1) Ag extraction from the basement by the penetration of deep-basinal brines, and (2) deposition in a structural trap through fluid mixing with recharge fluids. This model is comparable to that described worldwide for the origin of Pb-Zn, F, Ba, and U deposits near unconformities between basement and sedimentary basins. Similarities among the major Ag deposits from the Anti-Atlas (Imiter, Zgounder, Bou Azzer) strongly suggest that they resulted from a unique event, likely related to the opening of the Atlantic Ocean. The silver ores are superimposed on the same lineament as a preexisting uneconomic Pan-African Co-Ni-As system linked to magmatic intrusions, but Ag ores have no genetic relationship with them.