The Paleocene to Eocene southern Peru porphyry belt contains three significant porphyry Cu-Mo deposits at Cuajone, Quellaveco, and Toquepala. Ten new zircon U-Pb Sensitive High Resolution Ion Microprobe-Reverse Geometry (SHRIMP-RG) ages for Cuajone and Toquepala, together with published ages for Quellaveco, establish a magmatic history characterized by episodic events. Punctuated magmatism at Cuajone is distributed over approximately 13 m.y., at Toquepala over 8 m.y., and at Quellaveco over 6 m.y. The ages of the porphyry intrusions hosting or associated with the introduction of Cu and Mo at the three deposits show remarkable similarity, with emplacement beginning and ending at approximately 56.5 to 53.0 Ma at Cuajone, 57.0 to 54.0 Ma at Toquepala, and at 58.4 to 54.3 Ma at Quellaveco. Field relations coupled with the U-Pb ages for synmineral intrusions suggest very similar timing of the cupriferous hydrothermal systems, with the youngest pyritiferous and Cu-poor hydrothermal systems being associated with porphyry intrusions as much as 2 m.y. younger than significant Cu introduction. Overall, the porphyry Cu-Mo intrusive complexes represent the youngest magmatic complexes formed during the Late Cretaceous and early Tertiary arc, having formed prior to eastward migration of the magmatic locus.