Abstract The Andes, the world's largest non-collisional orogen, is considered the paradigm for geodynamic processes associated with the subduction of an oceanic plate below a continental plate margin. In the framework of UNESCO-sponsored IGCP 586-Y project, this Special Publication includes state-of-the-art reviews and original articles from a range of Earth Science disciplines that investigate the complex interactions of tectonics and surface processes in the subduction-related orogen of the Andes of central Chile and Argentina (c. 27–39°S). This introduction provides the geological context of the transition from flat slab to normal subduction angles, where this volume is focused, along with a brief description of the individual contributions ranging from internal geodynamics and tectonics, Quaternary tectonics and related geohazards, to landscape evolution of this particular segment of the Andes.