—The Vendian deposits of the Siberian Platform are represented by four regional horizons (from bottom to top): Nepa, Vilyuchan, Tira, and Danilovka. The TDS of brines in the Nepa and Vilyuchan horizons varies from 170.3 to 470.1 g/L, and the TDS in the overlying Tira and Danilovka horizons, from 84.6 to 583.1 g/L. Brines of Cl Na, Cl Na–Ca, Cl Ca–Na, Cl Ca, and Cl Ca–Mg types have been identified. The pH values of the brines vary from 3.0 to 7.0; acidic and weakly acidic brines (pH = 3.0–5.5) prevail. The redox potential Eh varies from –440 mV (highly reducing conditions) to +130 mV (oxidizing conditions), averaging –176 mV. Areal regional hydrogeochemical zoning is controlled by the outer (on the periphery of the Siberian Platform, where infiltration of meteoric waters took place) and inner feeding areas. The outer feeding areas bear infiltrogenic brines of different ages (group I), mostly of Cl Na composition. They are characterized by TDS ≤ 280 g/L, rNa/rCl ≤ 1.55, Cl/Br ≤ 2512, and average Ca/Cl = 0.3. The average values of the integrated brine metamorphization index S (according to S.L. Shvartsev) range from 50 to 200. In the intraplatform feeding areas, there are several phases of brines that underwent gravitational sinking into the Vendian horizons in the periods when Cambrian salt-bearing basins existed on the platform. These brines were metamorphosed during filtration along the fracture and fault zones. The intrusion of traps in the late Permian–early Triassic was accompanied by hydrothermal activity. The waters of the enclosing Cambrian dolomite horizons were heated to 800–1000 °C; their subsequent interaction with carbonate rocks and evaporites (in particular, chlorides) resulted in extrastrong saturated brines. These brines were also subjected to gravitational sinking into the Vendian reservoirs, which was the main cause of the inverse vertical hydrogeochemical zoning in the hydrogeologic subsalt formation. The brine metamorphism processes and temperature changes in the rock horizons during the intrusion of traps and their subsequent cooling led to a significant alteration of the enclosing rocks under interaction with brines and to salinization of the reservoirs, an increase in the total salinity of the brines, and catagenetic changes in their composition. The brines closest to the maximum saturation with halite were found in reservoir zones with the highest salinization and near faults and boundaries of intrusive bodies. During the pre-Vilyuchan, pre-Nepa, pre-Tira, and pre-Danilovka sedimentation breaks, infiltrogenic waters penetrated into the Vendian sediments. Geochemically, the sedimentogenic, infiltrogenic, and metamorphic strong brines (group II) have a predominantly Cl Ca or Cl Ca–Mg composition with TDS > 350 g/L. They are characterized by low rNa/rCl ratios (on average, 0.3), Cl/Br ≤ 100, high Ca/Cl values (on average, 0.4), and S > 250.