—The paper presents the geochemical and isotope characteristics of rocks and the U–Pb age and Lu–Hf isotope composition of zircons from three plutons of Paleoproterozoic granitoids in the Sharyzhalgai uplift (southwestern Siberian craton). The age of granitoids of the Toisuk (1838 ± 6 and 1827 ± 9 Ma), Nizhnii Kitoi (1846 ± 7 Ma), and Malaya Belaya (1863 ± 16 Ma) plutons corresponds to the Late Paleoproterozoic collision stage and is correlated with the time of mafic magmatism. The studied rocks have a wide range of silica contents. The Toisuk pluton is composed of a range of rocks from monzodiorites to granodiorites (granosyenites) and granites; the Nizhnii Kitoi pluton, of granodiorites and granites; and the Malaya Belaya pluton, of leucogranites. The rocks of the three plutons are highly ferroan, enriched in LREE, Th, and HFSE, and correspond in composition to A-type granitoids. A characteristic feature of melanocratic granitoids of the Toisuk and Nizhnii Kitoi plutons is extremely high contents of Ba: 4080–1500 ppm and 1560–990 ppm, respectively. Based on analysis of experimental data on the melting of various substrates and the results of numerical simulation, it is assumed that monzodiorite–granodiorites of the Toisuk pluton and granodiorites of the Nizhnii Kitoi pluton resulted from the differentiation/melting of a mafic source similar in Ba and Sr contents to intraplate continental basalts. The isotope compositions of zircon and melanocratic granitoids of the Toisuk (εHf from –6.0 to –10.7 and εNd from –5.3 to –10.2) and Nizhnii Kitoi (εHf from –5.0 to –8.1 and εNd = –4.0 and –5.1) plutons argue for the generation of their mafic sources from the enriched lithospheric mantle formed as a result of Neoarchean subduction processes. Vein granites of the Toisuk pluton and leucogranites of the Malaya Belaya pluton formed through the melting of quartz–feldspar (granodiorite) substrate. The contrasting isotope parameters of the Toisuk vein granites (εHf from –6.7 to –10.1, zircons, and εNd = –5.5, rock) and Malaya Belaya leucogranites (εHf from 2.9 to 5.9, zircons, and εNd from +0.7 to –1.9, rocks) indicate melting of the Archean and Paleoproterozoic crust, respectively. The more radiogenic Hf isotope composition of zircons from vein granites as compared with rocks of the Archean crust of the Irkut terrane is evident of the contribution of juvenile material to the granite formation.