The city of Izmir, located at the western end of Turkey, has experienced many strong earthquakes throughout its history. The southern coast of Izmir Bay, one of the most densely populated areas of Izmir, is located on deep alluvial sediments. It is important to determine the effect of local soil conditions on dynamic ground response in the study area, where thick loose water-saturated alluvial sediments exist. A database including geotechnical and geological information on the study area is constructed. Majority of the site is classified as D and E according to NEHRP provisions. Dynamic site response analyses are performed with EERA by utilizing the field and laboratory test results and earthquake time histories of moderate-scale earthquakes such as 1977 Izmir (ML = 5.3), 2003 Urla (Md = 5.6), and 2005 Uzunkuyu-Urla (ML = 5.9), which occurred in and nearby Izmir. In addition, a scenario ground motion generated by the Izmir Fault with a magnitude of 6.5, having an average distance of 10 km to the study area, is also considered. The output data obtained from the dynamic site response analyses are evaluated, and maps displaying variation in dynamic parameters on ground surface are prepared for the southern coast of Izmir Bay, Turkey. Consequently, the dynamic analyses performed with the soil models constituted for the study area verified the damage occurred in a close distance event of 1977 Izmir earthquake. The scenario earthquake resulted in peak ground accelerations more than 0.6g at the eastern and western ends of the study area. However, long distance events resulted in spectral amplifications by up to 5 times. With this study, it is emphasized that local soil conditions should be evaluated individually in the area of interest. Generation of a site-specific design spectrum is recommended for the areas located on deep alluvial sediments.