Collisional granitoid magmatism caused by the Early Neoproterozoic orogeny in the west of the Siberian craton is considered. New data on the petrogeochemical composition, U–Pb (SHRIMP II), Ar–Ar, and Sm–Nd isotopic ages of the Middle Tyrada granitoid massif in the northwestern Yenisei Ridge are presented. Plagiogranites, granodiorites, and quartz diorites of the massif are of calcareous and calc-alkalic composition. The elevated alumina contents and presence of accessory garnet permit them to be assigned to S-type granitoids. Their spidergrams show Rb, Ba, and Th enrichment, minimum Nb, P, and Ti contents, and no Sr depletion. The granitoids formed through the melting of plagioclase-enriched graywacke source, obviously Paleoproterozoic metaterrigenous rocks of the Garevka Formation and Teya Group (TNd(DM) = 2.0–2.5 Ga), judging from the isotope composition of the granitoids (TNd(DM-2st) = 2200 Ma and εNd(T) = –6.0) and the presence of ancient zircon cores (1.80–1.85 Ga). Formation of granitoids took place in the final epoch of the Grenville collision events in the late Early Neoproterozoic (U–Pb zircon age is 857.0 ± 9.5 Ma). In the Late Neoproterozoic, the granitoids underwent tectonothermal reworking caused by Vendian accretion and collision events on the southwestern margin of the Siberian craton, which explain the younger K–Ar biotite age, 615.5 ± 6.3 Ma.