Djerfisherite, a Cl-bearing potassium sulfide (K6Na(Fe,Ni,Cu)24S26Cl), is a widespread accessory mineral in kimberlite-hosted mantle xenoliths. Nevertheless, the origin of this sulfide in nodules remains disputable. It is usually attributed to the replacement of primary Fe–Ni–Cu sulfides when xenoliths interact with a K-and Cl-enriched hypothetical melt/fluid. The paper is devoted to a detailed study of the composition and morphology of djerfisherite from a representative collection (22 samples) of the deepest mantle xenoliths—sheared garnet peridotite, taken from the Udachnaya-East kimberlite pipe (Yakutia). Four types of djerfisherite were distinguished in the mantle rocks on the basis of morphology, spatial distribution, and relationships with the rock-forming and accessory minerals in the nodules. Type 1 was found in the rims of polysulfide inclusions in the rock-forming minerals of the xenoliths; there, it was younger than the primary sulfide assemblage pyrrhotite + pentlandite ± chalcopyrite. Type 2 formed rims around large polysulfide segregations (pyrrhotite+ pentlandite) in the xenolith interstices. Type 3 formed individual grains in the xenolith interstices together with other sulfides, silicates, oxides, phosphates, and carbonates. Type 4 was present as a daughter phase in the secondary melt inclusions which occurred in healed cracks in the rock-forming minerals of the xenoliths. Along with djerfisherite, the inclusions contained silicates, oxides, phosphates, carbonates, alkaline sulfates, chlorides, and sulfides. The results indicate that djerfisherite from the xenoliths is consanguine with kimberlite. Djerfisherite both in the sheared-peridotite xenoliths from the Udachnaya-East pipe and in different xenoliths from other kimberlite pipes worldwide formed owing to the interaction between the nodules and kimberlitic melts. Djerfisherite forming individual grains in the melt inclusions and xenolith interstices crystallized directly from the infiltrating kimberlitic melt. Djerfisherite bounding the primary Fe–Ni ± Cu sulfides formed by their replacement as a result of a reaction with the kimberlitic melt.