Basalt residual soil presents significantly disintegration by climatic influence. Most existing studies on disintegration of earth materials focus on rocks and minimal attention to soils and do not consider climatic impact. To investigate the effects of disintegration on residual soils derived from basalt, samples from Leizhou Peninsula, China, were first subjected to wetting-drying cycles, used for disintegration test in air, and then soaked to assess the effect of the dry and wet seasons that occur in the area. Results showed that repeated wet-dry cycles reduced the bonding within and between the aggregations. The majority of disintegrated material in the air transformed from coarse particles to fine particles, which may lead to severe disintegration, and disintegrated material in the water turned from lump or fragment eventually to mud. Furthermore, besides sesquioxides, other chemical components and minerals in soils performed a less prominent function in disintegration, which significantly deviated from the rocks containing expansive minerals. Disintegration aggravation with climate influences was evident in the structure degradation. Based on these results, the disintegration mechanism of the residual soil was interpreted.