Anhydrite cement causes significant heterogeneity within the San Andres reservoir of the Vacuum Field where it is associated with faults, fractures, karst zones and highly cemented dolomite intervals. The primary reservoir rocks within the Central Vacuum Unit of the Vacuum Field are dolomitized peloidal packstones, skeletal and ooid grainstones and fusulinid packstones. These rocks alternate with lower reservoir-quality dolomite intervals with variable amounts of anhydrite cement. Nodular and pore-filling fabric-selective anhydrite cements are common within the reservoir interval. Cross-plots of apparent matrix grain-density versus apparent matrix volumetric cross-section (ρmaa–Umaa cross-plots), combined with Vp/Vs seismic attributes and core data, provide insight into the vertical and lateral distribution of anhydrite within the San Andres reservoir. Anhydrite is generally concentrated in thin depositional cycles or intervals that are separated by relatively anhydrite-free cycles that exhibit relatively higher porosity and permeability. Lower Vp/Vs values correspond to higher percentages of anhydrite and are useful formapping anhydrite distribution. This evaluation of anhydrite distribution providesan estimate of the significant cementation-related heterogeneities within the reservoir that is useful for development-well planning and to target areas of bypassed pay.