Over the years, aluminum has been associated with a number of neurodegenerative diseases, however, it is the association of the metal with Alzheimer’s disease that has attracted the greatest attention and discussion in both the scientific literature and the lay press. In this chapter, we will discuss the background for this association and its implications for an understanding of its role in the etiopathogeneisis of age-related neurodegenerative disorders. Aluminum, although the most abundant metal in the earth’s crust, comprising 8% of the geologic mantle, is unique among the elements of abundance in that it is not considered to be essential...

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