A single crystal of orthopyroxene with composition Ca0.07Mg1.93Si2O6 (space group Pbca) has been investigated at high pressure and room temperature by in-situ X-ray diffraction using a diamond anvil cell. The unit-cell parameters have been determined at ten different pressures up to 10.16(5) GPa. In the pressure range investigated no evidences of phase transitions have been found. The pressure-volume data have been fitted with a third-order Birch-Murnaghan equation of state resulting in the following parameters: V0 = 838.26(8) Å3, KT0 = 110(1) GPa, K’ = 6.6(4). The Ca substitution in the pure orthoenstatite Mg2Si2O6 structure causes a slight increase in KT0 and a decrease in K’. The compressibility of a, b, and c unit-cell parameters is strongly anisotropic with a compressibility scheme βb >> βc >> βa. The structure evolution as a function of pressure has been determined at five different pressures up to 6.25(5) GPa. The M2 polyhedron undergoes the largest volume variation (~7.7%), whereas the volume variation of M1 is ~6.1%. The TA and TB tetrahedral volumes decrease by about 3% and 1.2%, respectively, without a discontinuity in the pressure range investigated.