Capsule pre-saturation has been traditionally employed to circumvent Fe loss from the charge to the container in petrological experiments. However, the method is time-consuming and fraught with theoretical and practical difficulties. An alternative method, based on the use of starting materials pre-enriched in Fe, is presented. Test experiments on two natural basalts, both non Fe-enriched and Fe-enriched with the addition of Fe oxides, have been carried out at 1 atm and 50 MPa (H2O-saturated), 1200 and 1250 °C, between NNO and NNO-1 and in Pt and Au80Pd20 capsules. Glasses and capsules were analyzed by electron microprobe. Fe-concentrations in the capsule near the glass interface strongly depend on the capsule material, being 5–10 times less for Au80Pd20 than for Pt. For non Fe-enriched compositions, Fe loss reaches −15% (Au80Pd20) and −60% (Pt). Increasing the level of Fe-enrichment reduces Fe loss, the amount of Fe alloyed with the capsule being compensated by the amount of Fe added to the starting composition. FeOt concentrations in high-pressure glasses bracket the nominal FeOt of the two starting basalts, demonstrating that Fe alloying has been successfully counteracted. Combination of AuPd containers with Fe pre-enriched starting materials offers excellent perspectives to solve the Fe loss issue in high-pressure experiments on basaltic compositions.