A single-crystal X-ray diffraction study of a sample of natural gedrite from North Carolina, USA, with the crystal-chemical formula ANa0.47B(Na0.03Mg0.97Mn0.02Ca0.04)C(Mg3.52Al1.15) T(Si6.31Al1.69)O22W(OH)2, up to a maximum pressure of 7 GPa, revealed the following bulk and axial moduli and their pressure derivatives: K0T = 91.2(6) GPa [K0T′ = 6.3(2)]; K0T(a) = 60.5(6) GPa [K0T(a)′ = 6.1(2)]; K0T(b) = 122.8(2.6) GPa [K0T(b)′ = 5.7(8)]; K0T(c) = 119.7(1.5) GPa [K0T(c)′ = 5.1(5)]. Gedrite has a much higher bulk modulus than anthophyllite (66 GPa) and proto-amphibole (64 GPa). All of the three axial moduli of gedrite are higher than those of these two other orthoamphiboles. The greater stiffness of gedrite along  is due to its high ANa content, which is almost zero in anthophyllite and proto-amphibole. The much greater stiffness parallel to the (100) plane of gedrite compared with the two other amphiboles is probably due to its high CAl content. A comparison is made with published data available for orthorhombic B(Mg,Mn,Fe) and monoclinic BCa amphiboles to identify correlations between crystal-chemistry and compressibility in amphiboles.