Understanding the deformation mechanisms that may operate in pyrite (FeS2) across a range of P-T conditions is important in deciphering the history of deformed ore deposits. Pyrite has frequently been considered a hard mineral, which deforms by cataclastic flow or diffusive processes, if at all, at temperatures <425°C. However, utilizing SEM-based orientation-contrast (OC) imaging and electron-backscatter diffraction (EBSD) techniques, plastic deformation can now be readily identified within pyrite grains. In this study, a series of pyrite-rich polymetallic ore deposits, deformed at low temperature metamorphic conditions (∼200-420°C), have been investigated. Results indicate that pyrite grains in all the ore deposits preserve internal lattice `distortion' or `bending' and therefore plastic deformation mechanisms have operated. Many pyrite grains in the ore deposits also contain low-angle (∼2°) sub-grain boundaries or `dislocation walls', indicating that both dislocation glide and creep have been the dominant deformation mechanisms at peak metamorphic conditions within the pyrite grains. These results suggest that the brittle-ductile transition in pyrite occurs at temperatures potentially as low as ∼200°C, far lower than implied from previous studies or the current pyrite deformation-mechanism map.