Devonian bactritids are described for the first time from South America. They come from siliciclastic rocks of the Talacasto Formation in the Precordillera Basin, west-central Argentina. The host strata span the Lochkovian–Emsian and contain other non-ammonoid cephalopods as well, thus refuting the alleged virtual absence of cephalopods in circumpolar Devonian basins from southwestern Gondwana (the Malvinokaffric Realm). We report Bactrites gracilis and Devonobactrites? sp., whose wide distribution contrasts with the endemic paleobiogeographic signature of some other taxonomic groups in these basins. Furthermore, new Lochkovian and Pragian records of Bactrites sp. provide new insights into the earliest bactritid records worldwide.