We present integrated in-situ zircon U-Pb and Hf isotope, with whole-rock Sr-Nd isotope and geochemical data for plutonic rocks of the Lohit Plutonic Complex (LPC) of eastern Himalayan in order to understand the age distribution and petrogenetic-tectonic evolution of the Transhimalayan batholiths in the eastern Himalaya, The plutonic rocks are gabbro, diorite and quartz-diorite in composition, have calc-alkaline signatures with metaluminous character and have an affinity with Gangdese I-type granitoids of southern Tibet. The enrichment of large-ion lithophile elements with highly depleted negative Nb anomalies is consistent with their origin in a subduction-related environment. Our LA-ICP-MS zircon U-Pb ages suggest that two major stages of magmatic emplacement took place at ca. 145 Ma (Early Cretaceous) for gabbro and during ∼100-90 Ma (early Late Cretaceous) for diorite and quartz-diorite. The zircon Hf isotopes in both the gabbro and diorite samples show high positive ƐHf(t) values between +11 and +20, suggesting crystallization from the juvenile crust or depleted mantle derived melts, as also constrained by the low initial 87Sr/86Sr ratios (0.7038 to 0.7045) and high positive ƐNd(t) values (+2.9 to +5.9). Results of REE modelling indicates that the source of these rocks is garnet lherzolite. Field observations, mineralogical and geochemical characteristics in conjunction with the isotopic database suggest that the Transhimalayan magmatic rocks in eastern Himalaya were generated by partial melting of the lithospheric mantle wedge and emplaced into the lower crust (∼ 25-30 km) during at least two major magmatic events that took place in the Cretaceous period.