Fluid inclusions have been observed and studied in rocks of most types of uranium deposits, except surflcial ones such as calcretes and the roll-type in sandstone. Temperatures of formation range up to nearly 400 °C but most deposits were formed at more moderate temperatures of 90–250 °C. It is evident from the relatively small number of studies, however, that the ore-forming process occurred at deeper levels than previously thought.

The chemistry of the fluids ranges from nearly pure water to very dense brines and CO2 is a common component. In some cases gas analyses allow determination of fO2 of the fluid, a key parameter for uranium transport and deposition.

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