The Egadi Islands-NW Sicily tectonic edifice represents a sector of the Apenninic-Maghrebian Chain, made of a set of tectonic units emplaced between late Miocene and early Pliocene times. The more recent tectonic activity has been referred by several authors to post-middle Pliocene compression and Pleistocene extension. Structural associations and kinematic indicators involving tyrrhenian marine, and more recent continental deposits, allows for recognition of a very recent tectonic stage in this chain sector, revealed by NW-SE, NE-SW and W-E trending strike-slip fault strands, with 1 cm-to-10 m scale displacements. The pattern of neotectonic faults fits well with a W-E trending regional simple shear system, composed of different orders of synthetic and antithetic structures and related to the evolution of the Southern Tyrrhenian margin. The recognised neotectonic faults may, therefore, represent the effects of the evolution of this recent shear zone.