We tested the validity of tracking seismic events as representations of chronostratigraphic surfaces at the subseismic, high-frequency-cycle level. A high-resolution geocellular model was generated from approximately 400 m of mixed clastic-carbonate sequences in the San Andres and Grayburg Formations in the Permian Basin, with 0.3–0.6 m layering and minimal upscaling. Realistic stratigraphic framework, facies, and velocity volumes were created by geostatistically mapping data from outcrop and subsurface sources while honoring state-of-the-art principles of stratigraphic and sedimentary analyses. Using the synthetic seismic data of different frequencies, the potential and pitfalls of using autotracked seismic horizons in building high-resolution reservoir models were tested. At the reservoir (meter) scale, the seismic reflections from flatter and thicker sediments with less facies and velocity heterogeneities tend to follow geologic-time surfaces; on the contrary, reflections from where thin sediments dip against flat strata with more facies and velocity heterogeneities tend to follow lithostratigraphy. For the latter seismic-guided reservoir modeling is not very precise, even with data as high as 140 Hz frequency. Therefore, for seismic-assisted reservoir prediction and modeling, the interpretation of seismic events is useful, but well calibration is critical.