Assessing the mechanical integrity of the caprock-reservoir system is necessary to evaluate the practical storage capacity for geologic storage. We used a combination of well-log and experimental data to estimate the statistical distribution (mean and variance) of rock mechanical properties of Cambrian-Ordovician strata within the Northern Appalachian region of Ohio and studied their heterogeneity throughout the study area. Empirical correlations between static-dynamic moduli of carbonate and sandstone formations of the Northern Appalachian Basin were developed. The state of stress (the orientation and magnitude of the maximum horizontal stress) for caprock and reservoir formations in the Cambrian-Ordovician sequence was determined at multiple well locations to understand the regional variability of these properties throughout the study area. The maximum horizontal stress () azimuth was estimated from image logs for six wells and S-wave anisotropy data for five wells. The magnitude was estimated by analytical and numerical modeling of stresses around the wellbore calibrated to the occurrence of wellbore breakouts and drilling-induced fractures in three wells as a function of depth. The results of assessing the magnitude and stress regime in the caprock and reservoirs in the Cambrian-Ordovician sequence using rock mechanical data acquired in this study, well-log data, and drilling data indicate that both parameters vary throughout the study area. In this work, we determined how integrating different types of data from multiple wells allowed us to estimate mechanical properties and characterize the spatial variability (laterally and vertically) of in situ stress for Cambrian-Ordovician caprock and reservoirs throughout the study area. A combination of different methods — numerical, analytical, and stress polygon — is used to estimate the in situ stress magnitude, especially , regionally on a formation-by-formation basis. The results of this work can be used to improve our understanding the complex nature of stress in the Northern Appalachian Basin.