In the Shenhu area, South China Sea, a study on P-wave attenuation in the hydrate-bearing sediments has been developed based on the Biot-Squirt (BISQ) porous medium model. However, the BISQ model has been proven to be inappropriate for the attenuation characteristics at seismic frequencies. We have adopted the patchy-saturation model, which is being increasingly considered to be more suitable for attenuation analysis at seismic frequencies in porous media, to study P-wave attenuation in the hydrate-bearing sediments in the Shenhu area, South China Sea. The theoretical modeling indicates that the P-wave attenuation at seismic frequencies is observed to decrease when the sediments contain gas hydrates. In the case studies in the Shenhu area, the interval inverse -factors from seismic reflection data were estimated, and the results indicate good agreement with the theoretical modeling.