The unexplored South Purulia Shear Zone (SPSZ) at the north of Singhbhum Shear Zone (SSZ) in Eastern India is a prospective zone for structural-guided hydrothermal mineralization. We carried out an integrated geophysical study using self-potential (SP), gradient-resistivity profiling (GRP), and gravity study across the SPSZ to identify the near-surface structural features and probable correlation with the uranium mineralization of the region. We studied a broad low SP, anomaly zone correlated with corresponding low-gravity and low-resistive zone across the same part of the study area. This conductive and low-density zone was identified as the width of the brittle-to-ductile and highly altered SPSZ. The 2D modeling of SP and residual gravity data along a northeast–southwest profile across the shear zone between Raghunathpur and Barabazar localities revealed the northerly dipping shear zone with an average width of . However, the 2D modeling of the SP data suggested numerous thick, sheet-type vertical and/or inclined structures intervening the shear zone, which were well correlated with the vertical structures delineated by the 2D gravity inverse model. The vertical alteration zones (density and conductivity) at -, 200-, and 400-m depths have been identified over this region. These alteration zones are likely to be mineralized zone because a hydrouranium anomaly has also been reported from those locations earlier. We studied the efficacy of an integrated approach using GRP, SP, and gravity surveys for the investigation of near-surface vertical to dipping conducting structures associated with uranium mineralization in such shear zone regions.