The Chandeleur Submarine Landslide Complex occurs on the upper Mississippi Fan of the Gulf of Mexico in approximately 1100 m of water, 200 km SE of New Orleans, Louisiana. This part of the Mississippi Fan received high sedimentation throughout the Pleistocene, causing high pore fluid pressure and abundant slope failures, though few as large as the Chandeleur. Given its large size, proximity to major coastal cities and seafloor infrastructures, we examine the Chandeleur Slide to understand what led to the initial slope failure and decipher its post-failure transport behaviour using 2D and 3D multichannel seismic surveys, high-resolution bathymetric data, and well logs. We find a large sediment mass with a translational-rotational behaviour that was displaced to the south/SE up to 40 km from the source area. The Chandeleur Slide includes extensional faulting in the headscarp area and compressional structures in the toe where confined by a natural ramp-like structure. Beneath the Chandeleur Slide, we identify a regional sand-rich unit (called the Blue Unit) that is known to be overpressured. Beneath the Blue Unit we observe an upward-migrating salt diapir. We suggest one possible scenario for the origin of the Chandeleur Slide is the combined effects of an upward-migrating salt diapir impinging on an already overpressured Blue Unit, leading to the initial failure. The initial failure was followed by retrogressive headwall retreat northward, which created the prominent scarp on the seafloor. In total, the Chandeleur Slide complex covers an area of about 1000 km² and contains about 300 km³ of sediment.