The region of Kyrgyzstan, Tajikistan and Uzbekistan includes five first-order tectonic units with an Early Paleozsoic sedimentary record, comprising North Tien Shan, Karatau Naryn, Turkestan–Alai, Zeravshan–Hissar and the Central Pamirs. Available palaeobiogeographical and palaeomagnetic data suggest that these were widely dispersed in the Ordovician. North Tien Shan, Karatau Naryn, Turkestan–Alai were separate microcontinents located in the low southern latitudes throughout the Ordovician in relative proximity to the western Gondwana margin. Zeravshan–Hissar and the Central Pamirs were also parts of the Gondwana supercontinent but were located in temperate latitudes. The geological literature on the Ordovician of the region is assessed to provide an updated palaeontological record, outline of lithostratigraphy and biostratigraphic correlation based on the International Chronostratigraphic Chart. The Ordovician biostratigraphy of Central Asia is mainly graptolite-based; however, that record is discontinuous, and the absence of detailed faunal logs and lack of monographic studies causes difficulty in precisely locating system and stage boundaries. Although an extensive faunal record has been documented, often it is based on preliminary taxonomical identifications which are not reliable for high-resolution biostratigraphy and tracing biodiversity patterns.