The Jurassic igneous rocks of Dronning Maud Land represent Karoo flood basalt magmatism in Antarctica. Fifty years of research has documented systematic differences between magmas associated with the Karoo rift-zone (Vestfjella and Ahlmannryggen) and the rift-shoulder (Sembberget, Kirwanveggen) settings. The 189–182 Ma rift-zone tholeiites were chemically diverse and mainly formed compound-braided flow fields which record several magnetic polarity reversals. In contrast, the c. 181 Ma rift-shoulder tholeiites were chemically uniform and formed thick tabular sheet lavas within a single normal polarity period. The volcanic architecture records a long initial phase of slow eruptions from shield volcanoes in the initial rift and a brief phase of voluminous fissure eruptions flooding the rift shoulder. All of the major magma types in the rift-zone and rift-shoulder settings belong to a Nb-depleted category of Karoo flood basalts and were mainly derived from depleted convective upper mantle by magmatic differentiation. Pyroxenite-rich mantle components may have been significant sources for the most enriched magma types. Geochemical fingerprints of recycled crustal material imply that the Nb-depleted Karoo tholeiites may have been derived from mildly subduction-modified parts of the same overall upper-mantle reservoir which has been associated with the Ferrar tholeiites.