The origin of different kinds of granitic rocks is examined within the framework of experimental studies of melting of metamorphic rocks, and of reaction between basaltic magmas and metamorphic rocks. Among the types of granitic rocks considered in this chapter, only peraluminous leucogranites represent pure crustal melts. They form by dehydration-melting of muscovite-rich metasediments, most likely during the fast adiabatic decompression that results from tectonic collapse of thickened intracontinental orogenic belts. All other granitic rocks discussed here represent hybrid magmas, formed by reaction of basaltic melts with metamorphic rocks of supracrustal origin. These hybrid rocks include Cordilleran granites, formed at or near convergent continental margins, strongly peraluminous ‘S-type’ granites, alumina-deficient ‘A-type’ granites, and rhyolites associated with continental flood basalts. The differences among these types of granites reflect differences both in their source materials and in the pressures at which mantle-crust interactions take place. In turn, these variables are correlated with the tectonic settings in which the magmas form. Hybrid mafic cumulates are also produced by mantle-crust interactions, simultaneously with the granitic melts. These cumulates range from orthopyroxene + plagioclase-rich assemblages at low pressure to clinopyroxene + garnet-rich assemblages at high pressure, and are known to be important constituents of the lower continental crust. With the exception of peraluminous leucogranites, generation of granitic magmas is almost always associated in space and time with growth, rather than just recycling, of the continental crust.