Deposits of proximal dust-derived alluvium (alluvial loess) within the catchments of the now semi-arid Flinders Ranges in South Australia record regionally synchronous intervals of fluvial entrainment, aggradation and down-cutting spanning the last glacial cycle. Today, these floodplain remnants are deeply entrenched and laterally eroded by ephemeral traction load streams. The north–south aligned ranges are strategically situated within the present-day transitional zone, receiving both topographically enhanced winter rainfall from the SW and convectional downpours from summer monsoonal incursions from the north. We develop a regional chronostratigraphy of depositional and erosional events emphasizing the Last Glacial Maximum (LGM). Based on 124 ages (94 accelerator mass spectrometry radiocarbon and 30 optically stimulated luminescence) from the most significant terrace remnants on both sides of the Ranges, we conclude that the last glacial cycle including the LGM was characterized by major environmental changes. Two pronounced periods of pedogenesis between c. 36 and 30 ka were followed by widespread erosion and reworking. A short-lived interval of climatic stability before c. 24 ka was followed by conditions in which large amounts of proximal dust (loess) were deposited across the catchments. These loess mantles were rapidly redistributed and episodically transported downstream by floods. The termination of this regime c. 18–16 ka was marked by rapid incision.