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This study investigates the internal anatomy and petrogenesis of the Tuolumne Intrusive Suite (TIS), which comprises metaluminous, high-potassium, calc-alkaline granitoids typical of the Sierra Nevada batholith. Although the TIS has often been cited as an example of a large magma chamber that cooled and fractionated from the margins inward, its geochemistry is inconsistent with closed-system fractionation. Most major elements are highly correlated with SiO2, but the scattered nature of trace elements and variations of initial Sr and Nd isotopic ratios indicate that fractional crystallization is not the predominant process responsible for its chemical evolution. Isotopic data suggest...

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