An approximately east-west-trending belt of porphyritic peraluminous granitoids, metamorphosed and deformed to augen gneiss, is exposed for 400 km across the Yukon-Tanana terrane. This belt consists of compositionally, texturally, and isotopically similar, concordant intrusions of augen gneiss in the Big Delta, Eagle, and Tanacross quadrangles of east-central Alaska, in the Fiftymile batholith of west-central Yukon Territory, and in two batholiths in the offset part of the Yukon-Tanana terrane northeast of the Tintina fault in southeastern Yukon Territory. Chemical analyses of augen gneiss from widely separated localities within the Big Delta intrusion suggest that the various samples are related by crystal fractionation. Comparison of major- and trace-element data from concordant layers of augen-poor gneiss and aplitic gneiss with similar data from adjacent augen gneiss suggests that the layers represent co-magmatic sills of more highly differentiated filter-pressed melt. Similarities between elemental abundances, particularly those of rare-earth elements, in augen gneiss from the large bodies in the Big Delta, Eagle, and Tanacross quadrangles, Alaska, and southeastern Yukon Territory suggest a common origin for these bodies. The peraluminous composition of the gneiss, its high initial 87Sr/86Sr ratio and high Th concentration indicate that the augen gneiss protolith contains a large component of crustal material. Geochronologic studies of augen gneiss in east-central Alaska and southeastern Yukon Territory indicate a Mississippian intrusive age and an early Proterozoic age for the crustal component. The augen gneiss bodies were intruded late in a middle Paleozoic volcanic-plutonic episode, and they may represent a deeply eroded continental magmatic arc. Regional amphibolite-facies metamorphism and mylonitization may have occurred late during the tectonic episode that resulted in intrusion of the porphyritic granitoid protoliths.