Subduction of the Paleo-Pacific slab beneath the North China Craton (NCC) has exerted a strong influence on the Mesozoic destruction of the craton. However, no Andean-type arc magmatism has been reliably identified in the eastern NCC. Here we report the occurrence of Jurassic arc-like lamprophyres in the Liaodong Peninsula, providing a snapshot of the Paleo-Pacific slab subduction beneath the NCC in the early Mesozoic. Zircon U-Pb dating of the lamprophyres yields consistent ages of 158–155 Ma for magma crystallization. These lamprophyres all exhibit typical arc-like trace element distribution patterns, but show a series differences in their radiogenic isotope compositions and the other geochemical variables. Type 1 lamprophyres exhibit weakly enriched Sr-Nd-Hf isotopes with (87Sr/86Sr)i ratios of 0.7075–0.7085, εNd(t) values of −3.9 to −1.3 and εHf(t) values of −5.4 to −0.3, whereas Type 2 lamprophyres exhibit moderately enriched radiogenic isotopes with (87Sr/86Sr)i ratios of 0.7096–0.7117, εNd(t) values of −12.2 to −7.6 and εHf(t) values of −12.8 to −4.7. There are also systematic differences in zircon Hf isotopes and whole-rock Ba/Th, Ba/La, Sr/Nd, Th/Nd, Th/Yb, and La/Sm ratios for the two types of lamprophyre. Taken together, these similarities and differences can be accounted for by metasomatic reaction of the cratonic mantle wedge with two properties of liquid phase derived from subducting Paleo-Pacific slab. One is aqueous solutions from the subducting basaltic oceanic crust, and the other is hydrous melts from the subducting terrigenous. The two properties of subduction zone fluids were incorporated in different proportions into the mantle sources of these lamprophyres. Accordingly, the lamprophyres were derived from the metasomatic mantle sources. This qualitative interpretation is verified by quantitative modeling of the geochemical transfer at the slab-mantle interface in a paleo-oceanic subduction zone. Therefore, the Jurassic lamprophyres in the eastern NCC provide the geochemical evidence for the crust-mantle interaction during the Paleo-Pacific slab subduction beneath eastern Asia in the early Mesozoic, when the chemical metasomatism by the slab-derived fluids would have weakened the cratonic mantle for its thinning and destruction in the Early Cretaceous.