Interactions between volcanic and tectonic processes affect the distribution, morphology, and volume of eruptive products in space and time. The Queréndaro area in the eastern Michoacán-Guanajuato Volcanic Field affords an exceptional opportunity to understand these relationships. Here, a Pleistocene lava plateau and 20 monogenetic volcanoes are vented from an active ENE-striking segment of the Morelia-Acambay fault system. Thirteen scoria cones are aligned along this structure, vented from an extensional gap in between two rotated hanging wall blocks of a listric fault. A new geological map, volcanic stratigraphy, and 40Ar/39Ar dating indicate that this lava plateau and volcanic cluster were emplaced from 0.81 to 0.25 Ma by 11 intermittent eruptive epochs separated by ca. 0.05 Ma, emplacing a total magma volume of 5 km3. Petrography and chemistry of rocks suggest that all volcanic structures were fed by three different magma batches but vented from independent feeder dikes. Our results indicate that preexisting faults exert a strong influence on volcanic spatial and temporal distribution, volcanic morphology, magma volume, and eruptive dynamics in this area. ENE-breached and ENE-elongated scoria cones indicate parallel subsurface fissure and feeder dikes. Additionally, points of maximum fault dilation at depth related to a transtensive state of stress coincide with less fragmented deposits and larger magma volumes. Furthermore, this study raises important questions on the geodynamics of volcano-tectonic interactions possible in similar monogenetic volcanic alignments worldwide.