Combined petrofabric, microstructural, stable isotopic, and 40Ar/39Ar geochronologic data provide a new perspective on the Cenozoic evolution of the northern Snake Range metamorphic core complex in east-central Nevada. This core complex is bounded by the northern Snake Range detachment, interpreted as a rolling-hinge detachment, and by an underlying shear zone that is dominated by muscovite-bearing quartzite mylonite and interlayered micaschist. In addition to petrofabric, microstructural analysis, and 40Ar/39Ar geochronology, we use hydrogen isotope ratios (δD) in synkinematic white mica to characterize fluid-rock interaction across the rolling-hinge detachment. Results indicate that the western flank of the range preserves mostly Eocene deformation (49–45 Ma), characterized by coaxial quartz fabrics and the dominant presence of metamorphic fluids, although the imprint of meteoric fluids increases structurally downward and culminates in a shear zone with a white mica 40Ar/39Ar plateau age of ca. 27 Ma. In contrast, the eastern flank of the range displays pervasive noncoaxial (top-to-the-east) fabrics defined by white mica that formed in the presence of meteoric fluids and yield Oligocene–Miocene 40Ar/39Ar ages (27–21 Ma). Evolution of the Oligocene–Miocene rolling-hinge detachment controlled where and when faulting was active or became inactive owing to rotation, and therefore where fluids were able to circulate from the surface to the brittle-ductile transition. On the western flank (rotated detachment), faulting became inactive early, while continued active faulting on the eastern flank of the detachment allowed surface fluids to reach the mylonitic quartzite. The combined effects of synkinematic recrystallization and fluid interaction reset argon and hydrogen isotope ratios in white mica until the early Miocene (ca. 21 Ma), when the brittle-ductile transition was exhumed beneath the detachment.