U-Th-Pb analyses of zircons from an ortho-augen gneiss body in the Yukon-Tanana Upland of east-central Alaska yield strong evidence for the presence of early Proterozoic material in this area. U-Pb data define a chord that intersects concordia at about 2,300 and 345 m.y. We consider two interpretations: (1) the protolith was intruded during the Proterozoic and was subsequently metamorphosed in the Paleozoic or, more likely, (2) the protolith was intruded in the Paleozoic and incorporated material of Proterozoic age. An Sm-Nd model age of about 1,900 m.y. on a whole-rock sample of augen gneiss is additional evidence for the presence of Proterozoic material in the gneiss. K-Ar and U-Th-Pb dating of mica and sphene, respectively, reveal that younger thermal events occurred at least as recently as 110 m.y. ago.